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欧盟评估一种食品酶的安全性

放大字体  缩小字体 时间:2022-03-10 10:25 来源:食品伙伴网 作者: 泽夕   
核心提示:2022年3月8日,欧盟食品安全局就一种非还原端α-l-阿拉伯呋喃糖苷酶(non-reducing end α-l-arabinofuranosidase)的安全性评价发布意见。
   食品伙伴网讯  2022年3月8日,欧盟食品安全局就一种非还原端α-l-阿拉伯呋喃糖苷酶(non-reducing end α-l-arabinofuranosidase)的安全性评价发布意见。
 
  据了解,这种食品酶是由转基因里氏木霉菌株NZYM-GV生产的,旨在用于谷物处理,以生产淀粉和面筋部分。
 
  经过评估,专家小组认为,在预期的使用条件下,不能排除饮食暴露引起过敏和诱发反应的风险,但这种情况发生的可能性很低。根据所提供的数据,评估小组得出结论,该食品酶在预期的使用条件下不会引起安全问题。部分原文报道如下:
 
  The food enzyme non-reducing end α-l-arabinofuranosidase (α-l-arabinofuranoside non-reducing end α-l-arabinofuranosidase; EC 3.2.1.55) is produced with the genetically modified Trichoderma reesei strain NZYM-GV by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in grain treatment for the production of starch and gluten fractions. Since residual amounts of total organic solids (TOS) are removed by washing and purification steps applied during grain treatment, the estimation of a dietary exposure is considered not necessary. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1,116?mg TOS/kg body weight per day, the highest dose tested. Similarity of the amino acid sequence to those of known allergens was searched and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is considered to be low. based on the data provided and the removal of TOS during the grain treatment, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
 
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日期:2022-03-10
 
 
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